Celtic's second-half implosion saw them reduced to nine players against Feyenoord as they once again failed to claim a Champions League away win.
They started brightly and had Daizen Maeda threaten early, but Calvin Stengs' free-kick stunned the Hoops just before half-time.
That sparked the Dutch champions into life and Gustaf Lagerbielke conceded a penalty and was shown a second yellow card before Joe Hart saved the spot kick.
The night then went from bad to worse with substitute Odin Thoago Holm shown a straight red for a reckless challenge.
Alireza Jahanbakhsh wrapped up the win for Feyenoord who also had efforts disallowed either side of that goal.
Celtic return to Scottish Premiership action on Saturday at Livingston, live on Sky Sports. Kick-off 12.30pm.
Their next Champions League match is at home to Lazio on October 4. Kick-off 8pm.Read on m.allfootballapp.com