The Red Devils have only been able to call upon Martinez on 11 occasions this season due to injury, and his latest issue — related to his calf — has kept him out since the end of March.
Rashford, meanwhile, has not played for the 20-time English champions since limping off during the FA Cup semi-final with Coventry City on April 21.
The England international has missed his side's last three Premier League matches against Sheffield United, Burnley and Crystal Palace.
Martinez's last outing in England's top flight, meanwhile, was the 1-1 draw with Brentford on March 30.
Lisandro Martinez, Marcus Rashford train on ThursdayThe Argentina international was forced to undergo a second foot operation of 2023 towards the start of the season, eventually returning against Tottenham Hotspur in the middle of January.
However, the centre-back then suffered a knee problem against West Ham United on February 4 before picking up the calf issue which has seen him miss five straight league fixtures.
Martinez's return for the final three league matches of the season, and the FA Cup final with Manchester City on May 25, would be a monumental boost for Erik ten Hag's side.
Casemiro has recently been used as a centre-back due to the team's problems in that area of the field, and he was joined by Jonny Evans in the middle against Crystal Palace last time out, with the Northern Ireland international called upon after returning from injury due to a muscular problem for Harry Maguire.
Ten Hag will speak to the media on Friday afternoon and is likely to reveal whether
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