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Newcastle face an early test of their Premier League aspirations this season when they take on Manchester City, while Chelsea's £115 million ($146 million) midfielder Moises Caicedo is set to make his debut at West Ham.
Tottenham are looking for the scalp of Manchester United on Saturday in their first home game since the departure of Harry Kane.
AFP Sport looks at the best of the action on the second weekend of the Premier League season:
Can Newcastle dream?The Magpies head to the Etihad top of the table after a 5-1 demolition of highly-fancied Aston Villa last weekend.
Sandro Tonali and Harvey Barnes scored on their debuts, while Alexander Isak's classy double was further evidence of the Swede's rise to becoming one of the Premier League's top marksmen.
After qualifying for the Champions League for the first time in 20 years, there have been doubts over how Eddie Howe's men will balance the demands of domestic and European football.
5 Arsenal star who could replace injured Gabriel Jesus ahead of Man City tie
FootballBut they could be facing City at the perfect time.
Pep Guardiola sarcastically thanked the Premier League for scheduling his side to play just three days after a draining UEFA Super Cup win over Sevilla in the baking heat of Athens.
City will be without Kevin De Bruyne, while Bernardo Silva, Ruben Dias and John Stones are doubts after playing no part in the Greek capital in midweek.
Newcastle have not won away to City in the Premier League in 23 years.
But their rise since a takeover from the Saudi sovereign wealth fund less than two years ago has been rapid.
Beat the champions on Saturday and talk on Tyneside may turn to dethroning
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