Chelsea and Tottenham meet at Stamford Bridge each hoping to put an almighty dent in the European ambitions of their London rivals.
Mauricio Pochettino faces such an injury crisis that his team has practically been picked for him.
Meanwhile, Ange Postecoglou will need to wrestle his players from a stupor after back-to-back defeats, although their inspired second-half in their 3-2 loss to Arsenal gives hope.
Should either manager be in doubt about who to pick, they would do well to listen to Mail Sport's authoritative advice below.
Without further ado, we present Mail Sport's combined XI. What could go wrong?
Goalkeeper: Guglielmo Vicario (Tottenham)
Provided he doesn't let anyone undo his gloves, Vicario is a fairly straightforward pick here.
He's the archetypal modern goalkeeper, ranking highly in distribution statistics and capable of sweeping if needed.
There are doubts about his ability to command his area - Micah Richards was unimpressed with his sheepishness in the 3-2 loss to Arsenal and Spurs conceded two goals from corners.
Djordje Petrovic is a fine goalkeeping option for Chelsea in a mid-table season, but Mail Sport prefers Vicario.
Right-back: Pedro Porro (Tottenham)
Porro has found a happy home at Spurs and is well-suited to their play style.
He has been a good creator charging up the wing for Ange Postecoglou, notching seven assists, although his last was in January.
It would have been a coin toss against Malo Gusto, whose crossing has been a sight to behold, but he is out after sustaining a knee injury against Manchester City.
Centre-back: Cristian Romero (Tottenham)
It has its imperfections, but Romero's partnership with Micky van de Ven is something Spurs can build on for seasons to come.
Aggressive, swashbuckling,
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