It may not have the title implications of bygone seasons but upsetting their bitter rivals' title ambitions will be enough to motivate Manchester United, who themselves still have faint Champions League hopes.
Jurgen Klopp's men head to the Theatre of Dreams fighting the bitter taste of the 4-3 FA Cup defeat which left the German's fairytale quadruple in tatters.
Liverpool have suffered defeats in their last two visits to Old Trafford, since a Mo Salah hat-trick led them to a famous 5-0 victory in 2021, and know they cannot slip up if they hope to clinch their second Premier League title under Klopp.
Memories of Amad Diallo's last-gasp winner will haunt the travelling fans but that would be quickly forgotten if they can produce another victory on enemy territory.
Liverpool have easily one of the strongest squads in world football, but how many of Ten Hag's stars would make a combined XI? Here, Mail Sport runs the rule over the two sides ahead of the game.
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Goalkeeper
With Alisson still on the sidelines, both Andre Onana and Caoimhin Kelleher have a reasonable case to wear the gloves.
Despite his Champions League woes, Onana has had a solid debut season, with only Arsenal's David Raya and Jordan Pickford of Everton having kept more clean sheets in the Premier League.
While some of the criticism for his European performances against Bayern Munich and Galatasaray were deserved, with his side crashing out in the group stage for the first time since 2015-16, he has grown into one of the most pressured roles in football. Just remember how long it took David de Gea to earn that shirt.
Young Irishman Kelleher has admirably filled the sizeable boots of Alisson, who should return from a thigh injury in the next few weeks
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