Stamford Bridge will play host to the intriguing battle between two of the giants of English football, with both teams looking to return to winning ways following draws on Saturday; Chelsea were held to a 2-2 by Burnley, while Man United shared the spoils with Brentford in West London.
Man United remain sixth, nine points behind fifth-placed Tottenham Hotspur, who have played a game more, with fifth likely to be enough to secure Champions League football for next term.
Chelsea, though, are down in 12th position, 17 points behind Spurs, although the Blues do have two matches spare on Ange Postecoglou's side.
Man United will be aiming to stretch their unbeaten run against Chelsea in the Premier League to 13 matches on Thursday, winning five and drawing seven of their last 12 with the London club in England's top flight.
April a successful month for Man United in the Premier LeagueMan United have been victorious in more matches (80) and have a higher win percentage (59.7%) in April than any other side in the history of the Premier League.
Erik ten Hag's side have five league games to come this month, following the clash against Chelsea with a home fixture against title-challenging Liverpool on Sunday afternoon.
The Red Devils will then head to Bournemouth on April 13, before ending the month with league fixtures against relegation-threatened duo Sheffield United and Burnley.
Man United will also tackle Championship outfit Coventry City in the semi-finals of the FA Cup this month, but there is little room for error in the league if a top-five finish is to be
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