Eddie Howe says Newcastle travel to Borussia Dortmund in search of all three points in Champions League Group F despite confirming Dan Burn will be out long-term with a back injury.
Borussia Dortmund put in a brilliant performance at St James' Park a fortnight ago, with Felix Nmecha's goal giving them a 1-0 win.
Victory against the Magpies lifted Dortmund into second place in the group, above Howe's men - who also have four points from their first three fixtures - by virtue of their head-to-head record.
Newcastle head into Tuesday's return fixture off the back of wins against Manchester United and Arsenal in their last two matches.
Howe said: "It's in-built in me, I think every game is a must-win, and the term is probably overused in football.
"But it's the only way that we prepare. We prepare to win every game, we never have anything else in our minds and we will prepare to win this one."
On Burn's injury absence, Howe added: "Dan will be out long term, a couple of months specualtively. He landed on his spine. I think he has a problem with the base of his spine.
"He's been gigantic for us since he signed for lots of reasons as I have continually said. But it is something we have to roll with it."
Edin Terzic has warned Borussia Dortmund they will have to be even better than they were at St James' Park if they are to complete a Champions League double over Newcastle.
They head into the return at the Signal Iduna Stadium still smarting from Saturday's 4-0 drubbing by arch-rivals Bayern Munich, and with head coach Terzic expecting a Magpies backlash.
He said: "We need to improve because we know that they [Newcastle] are not happy with the way that they performed at St James' Park and they will want to do much better tomorrow
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