The Eagles recorded a 1-0 victory at Old Trafford in the Premier League back in September, with Joachim Andersen netting the only goal of the contest in Manchester.
Palace will now be aiming to complete a league double over the 20-time English champions for the first time.
Man United comfortably lead the overall head-to-head record between the two sides, posting 41 wins to Palace's 11, while there have also been 13 draws.
Unsurprisingly, the majority of Palace's success over the Red Devils has come in recent years, winning four of the last 10 matches between the two teams in all competitions.
Palace looking for first ever league double over Man UnitedMan United were last victorious away to Palace in July 2020, running out 2-0 winners at Selhurst Park courtesy of goals from Marcus Rashford and Anthony Martial under the leadership of Ole Gunnar Solskjaer.
The Red Devils actually triumphed in eight of their first 11 away Premier League fixtures against Palace but are now winless in their last three, drawing twice and suffering one defeat.
Erik ten Hag's side have only lost one of their last nine matches in all competitions, but they have been victorious in just one of their last six in the Premier League.
The team's last four league games have produced one win and three draws, sharing the points with relegation-threatened Burnley last weekend.
Man United can no longer secure Champions League football next season, with the team instead battling to secure either Europa League or Conference League action during the 2023-24 campaign.
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