On Saturday evening, the Blues succumbed to a 1-0 defeat to Manchester City in the FA Cup semi-finals, Bernardo Silva scoring the decisive goal six minutes from time.
The loss came on the back of numerous chances being missed before City's winning strike, Nicolas Jackson guilty of squandering the clearest opportunities.
As a result, Chelsea were on the wrong end of a narrow scoreline in a Wembley fixture for the second time this season despite generally having the better of the game.
Pochettino's side are now left to try to earn European qualification through the Premier League, Chelsea currently sitting down in ninth position in the standings.
Chelsea can 'build on positives'This important game in the Premier League comes just three days after losing a high-profile fixture, not ideal circumstances when Chelsea are under pressure to finish in the top seven.
Nevertheless, Pochettino has suggested that he retains total confidence in his squad ahead of attempting to end their recent poor record against one of their London rivals.
Speaking to reporters, as quoted by football.london, the Argentine said: «The mood is good because I think we play a really good game. We play so well, against a team that is one of the best in the world. I think our performance was really good with some very positive things that we need to take.
»In the last few minutes we conceded a goal we shouldn't concede but I think that is part of football. We created so many chances against a team, for me, that is the best team in the world. That is a good thing to keep working in this way and
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