Marc-Andre ter Stegen, Gavi, Marcos Alonso, Inigo Martinez, Joao Cancelo and Raphinha are all unavailable for selection in Seville due to injury problems.
Meanwhile, Andreas Christensen is also absent due to the muscular problem which he picked up in the team's 3-1 success over Unionistas in the Copa del Rey on Thursday.
The squad has received a double boost from the cup fixture, though, with Ronald Araujo and Lamine Yamal available again after missing out against Unionistas through suspension.
Hector Fort and Pau Cubarsi could both be in line for minutes due to the defensive absentees, although it seems more likely that Sergi Roberto will line up on the right of the back four.
Barcelona have not been in La Liga action since recording a 2-1 win over Las Palmas on January 4, and they are currently fourth in the table, eight points behind the leaders Girona.
«Tomorrow we have a tough match. They haven't lost at home. We're starting the second half of the season with all our enthusiasm, knowing that we're behind Girona and Madrid, but we'll be able to come back from behind,» Barcelona boss Xavi told reporters during his pre-match press conference.
«It's the best scenario to see a good Barca and win, based on good play… defensively we are very good, we are also very good at pressing high. We win balls back and we are excellent in strategy.
»I'm talking about the last pass, to choose well, but we have very young players. I despair because I see the pass, which was my quality, but it's a matter of time. It was not a criticism. It's a feeling of desperation from me. The youngsters have to keep trying."
Xavi also remains
Read on sportsmole.co.uk