The Catalans are aiming to reach the quarter-finals of the competition they last won in 2015, with the tie level at 1-1 after the first leg in Italy. Xavi is missing three key midfielders in Pedri, Gavi and Frenkie de Jong, as well as Ferran Torres and Alejandro Balde.
Lamine Yamal could prove crucial in the Champions League last 16 second-leg clash with Napolion Tuesday at the club's temporary Olympic Stadium home.
The 16-year-old winger became the youngest player ever to feature in the Champions League knock-out stages as he impressed in the 1-1 first-leg draw in the south of Italy.
Barcelona confirmed lineup: Ter Stegen (GK); Kounde, Araujo, Cubarsi, Cancelo; Fermin Lopez, Christensen, Gundogan; Lamine Yamal, Lewandowski and Raphinha.
Napoli confirmed lineup: Meret (GK); Di Lorenzo, Rrahmani, Juan Jesus, Mario Rui; Zambo Anguissa, Lobotka, Traore; Politano, Osimhen and Kvaratskhelia.
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