Joe Gomez is named in place of Andy Robertson and Darwin Nunez starts for Liverpool against Brighton at Anfield.
Robertson injured his ankle earlier this week during Scotland's defeat to Northern Ireland and Gomez, who played twice for England during the break, is named on the left side of defence as a result.
Jarell Quansah keeps his place at centre-back alongside captain Virgil van Dijk, despite Ibrahima Konate playing for France during the round of international fixtures.
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Jurgen Klopp selects a midfield three of Wataru Endo, Alexis Mac Allister and Dominik Szoboszlai while Nunez is named up top between Mohamed Salah and Luis Diaz.
Nunez was not part of the Uruguay squad during the international break after a minor muscle injury picked up in the 4-3 FA Cup loss at Manchester United. The forward stayed on Merseyside to work on his fitness for today's game.
Curtis Jones is not fit enough for the bench despite Klopp suggesting the midfielder was making good progress on an injury sustained in the mid-February win over Brentford in his Friday press conference.
Jayden Danns, James McConnell and Bobby Clark are all part of the subs bench against Roberto De Zerbi's Seagulls.
Liverpool: Kelleher; Bradley, Quansah, Van Dijk, Gomez; Endo, Mac Allister, Szoboszlai; Salah, Nunez, Diaz.
Subs: Adrian, Konate, Tsimikas, McConnell, Gravenberch, Clark, Elliott, Gakpo, Danns.
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