Adi Huetter's side brushed aside lowly Metz 5-2, courtesy of three goals in quick succession from Takumi Minamino, Maghnes Akliouche and Vanderson before Folarin Balogun added a second-half brace either side of Pape Amadou Diallo and Ibou Sane strikes for the hosts.
The win lifts Monaco to second place with 49 points, 10 behind leaders Paris Saint-Germain who travel to Marseille for 'Le Classique' on Sunday.
Japanese international Minamino gave Monaco the perfect start after four minutes when he turned on Eliesse Ben Seghir's pass near the six-yard box and rifled a shot past Alexandre Oukidja in the Metz goal.
Akliouche doubled the lead on 10 minutes, pouncing on Kevin Van Den Kerkhof's lax touch in the centre circle before driving through the middle of the pitch and rolling a composed left-footed finish past the 'keeper.
The tie was effectively over just six minutes later when Vanderson guided a stretching volley into the far corner from an Aleksandr Golovin cross.
Metz goalkeeper Oukidja gifted Monaco a fourth goal on 76 minutes when he tried a backheel past Balogun, but the striker blocked it with his leg and into the open goal. Two minutes later, Diallo snatched a goal for 17th-placed Metz to give them hope and Sane tapped home on 84 minutes.
But Balogun settled any potential nerves for Monaco, converting from a corner to send the principality side two points ahead of third-place Brest, who play at Brittany rivals Lorient on Sunday. Later Saturday, Lyon host Reims in a mid-table clash at the Groupama Stadium.
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