The Liverpool vice-captain has been sidelined since the Reds' 3-1 win over Burnley in February, missing the last nine games with a knee injury.
Despite being at Wembley on Saturday, the 25-year-old was forced into a watching brief, which is something that has become a recurring theme during his England career.
Widely described as a stop-start one to this point, the Liverpool defender's journey with the Three Lions has been plagued with frequent interruptions, evident in his modest tally of only 23 caps since his debut nearly six years ago.
Given the apparent preference for Kyle Walker and Kieran Trippier at right-back for England, Liverpool's standout has already started in midfield during several Euro 2024 qualifiers over the past year.
Southgate was eager to persist with the experiment before the commencement of this summer's Euros in this month's friendlies against Brazil and Belgium, but those plans were derailed by Alexander-Arnold's current knee injury.
Having also missed games against Scotland and Belgium last month due to a hamstring problem, the 25-year-old has not had the opportunity to prove to the England boss that he can thrive in midfield against tougher opposition.
Arguably, the best England midfield trio on paper is composed of Declan Rice, Jude Bellingham and Alexander-Arnold.
However, for now, it seems that the likelihood of seeing those three playing together in the English engine room remains more of an idea than a tangible reality, as they have never started together
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