The Yorkshire giants went into Friday's contest at Loftus Road with the opportunity to move four points clear of third-placed Ipswich Town in the Championship standings.
Instead, Leeds would suffer their heaviest defeat of the campaign as the Hoops starved off any relegation fears with two goals in either half.
Ilias Chair and Lucas Andersen put QPR in control by the 22nd minute before Lyndon Dykes and Sam Field got on the scoresheet after the break.
While Marti Cifuentes and his squad were able to celebrate joyously with their supporters, Leeds were left to reflect on handing the advantage in the automatic promotion race to Ipswich.
What does QPR win mean for promotion race?Leicester City were the main beneficiaries on Friday evening as the Foxes were confirmed as champions, but Ipswich now have the chance to take full advantage.
The Tractor Boys require a maximum of five points from their final three games to secure second place, those fixtures against Hull City, Coventry City and Huddersfield Town.
With Leeds not playing again until next Saturday, two wins for Ipswich on Saturday and Tuesday will earn the runner-up spot before Farke's team are back in action.
What did Farke have to say?Although Farke was complimentary of QPR's victory in the capital, the German hinted that there were a number of factors why Leeds were so overawed in their most important game of the season.
Speaking to Sky Sports, Farke said: «First of all, congratulations to QPR. It's a well-deserved win for them and we have to accept the loss. Decisive for the game were the first 15 minutes. We were poor in this period,
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