Arsenal suffered a blow when Declan Rice was forced off during the north London derby against Tottenham on September 24.
The Gunners' record signing started the match at Emirates Stadium but could not continue beyond halftime, with the scores level at 1-1.
Rice had missed just 14 minutes of Arsenal's competitive games since the Community Shield back in August and his absence was keenly felt in the second half, not least because replacement Jorginho was at fault for Spurs' second equaliser of the day.
The bigger concern for Arsenal fans now is whether Rice faces a longer spell out of action, with games to come against Brentford in the EFL Cup, Lens in the UEFA Champions League, and Bournemouth, Manchester City and Chelsea in the Premier League.
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Rice was substituted at halftime of Arsenal's Premier League match with Tottenham on September 24.
He played the full first half of the game at Emirates Stadium and did not appear to be in any particular discomfort, although he had had a relatively quiet performance in the middle of midfield.
Rice did not return for the second half, with Jorginho brought on as his replacement. It was the Italian's error in allowing James Maddison to dispossess him that saw Son Heung-min equalise barely a minute after Bukayo Saka put Arsenal back in the lead.
Rice was on the Arsenal bench and, according to Sky Sports in the UK, he had strapping on his left calf.
There is obviously no indication yet how long Rice could be sidelined. Arsenal manager Mikel Arteta will provide more clarity when he speaks to the media.
Rice became Arsenal's record signing when he joined from West Ham in July 2023.
The 24-year-old was signed for a reported initial fee of £100 million/$122.4
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