Kobbie Mainoo is in line for his first England start against Belgium at Wembley on Tuesday night, with Ben Chilwell also expected to receive another chance at left-back.
Mainoo made his senior debut off the bench against Brazil on Saturday. Before then, the 18-year-old Manchester United midfielder had only played international football as high as U19 level.
Mainoo was initially named in the U21 squad for this month's matches but was quickly promoted to Gareth Southgate's senior side.
England are set to name a young midfield against Belgium, with 20-year-old Jude Bellingham - who has recovered from the cramp that forced in the defeat to Brazil on Saturday - and 25-year-old Declan Rice, who will captain the side on his 50th appearance, alongside Mainoo.
Chilwell struggled against Brazil's wingers at Wembley but is expected to be given another chance to stake a claim for a place in the Euro 2024 squad.
Joe Gomez is likely to again start on the bench but is set to be handed more minutes as a substitute.
Southgate has said he needs to explore other full-back options, with Luke Shaw's injury meaning he is unlikely to play much - if at all - for Manchester United before the end of the season.
The England boss says he cannot see his first-choice left-back being available to play a potential seven matches in the finals in Germany this summer.
Ivan Toney could start against Domenico Tedesco's team as he bids to secure a place in the Euros squad ahead of Ollie Watkins, who was named in the XI against Brazil.
Sky Sports News senior reporter Rob Dorsett:
There's been a big clamour for Kobbie Mainoo to be involved with England on a more regular basis. Remember, he skipped the U21s because Southgate wanted to promote him all the way up from
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