Jurgen Klopp makes six changes for the visit of Southampton in the FA Cup as Lewis Koumas makes his senior debut up top.
Koumas is part of a front three that also contains Cody Gakpo and Harvey Elliott as the Reds go in search of a place in the quarter-finals, where they will travel to either Nottingham Forest or bitter rivals Manchester United.
Jarell Quansah partners captain Virgil van Dijk with Kostas Tsimikas deputising for Kostas Tsimikas on the left and Conor Bradley once more filling in for Trent-Alexander Arnold on the right.
In midfield, Trent-Alexander Arnold starts in an unfamiliar No.6 role given the injury issues that are blighting the Reds at present, particularly in the engine room where they are without Thiago Alcantara, Dominik Szoboszlai, Wataru Endo, Stefan Bajcetic and Ryan Gravenberch.
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Gomez is joined by James McConnell and Bobby Clark, who are both handed starts after their impressive showings off the bench at Wembley on Sunday.
Injuries to Endo and Gravenberch, both sustained in the Carabao Cup win at the weekend, mean the Reds are currently without 13 first-team players in total ahead of Saturday's visit to Nottingham Forest in the Premier League.
Liverpool: Kelleher; Bradley, Quansah, Van Dijk; Tsimikas; Gomez, McConnell, Clark; Elliott, Gakpo, Koumas. Subs: Adrian, Konate, Diaz, Mac Allister, Scanlon, Gordon, Nallo, Danns, Nyoni.
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