Jurgen Klopp claimed Liverpool need "miracles" to get his walking wounded back in time to boost their quadruple bid.
Klopp's side defied a host of injuries to win the League Cup 1-0 against Chelsea in Sunday's final at Wembley.
But Liverpool midfielder Ryan Gravenberch added to the club's mounting fitness crisis when he was stretchered off in the first half.
Gravenberch will miss at least two matches, starting with Wednesday's FA Cup fifth round tie against Southampton at Anfield.
Wataru Endo is also a doubt for the visit of the Championship promotion chasers Southampton after he left Wembley on crutches and wearing a protective boot.
That leaves Klopp without 13 first team players, including Mohamed Salah, Darwin Nunez and Dominik Szoboszlai, as the Reds try to add the Premier League, FA Cup and Europa League to last weekend's silverware.
"We need miracles with a few players. I don't want to rule them out for too long," Klopp told reporters on Tuesday.
"But it is touch and go with a lot of players who were not available for the final: Darwin, Mo, Dom - we have to see what they can do (on Tuesday).
Jürgen Klopp previewed our #EmiratesFACup meeting with Southampton by holding a press conference earlier today ⤵️
"In an ideal world you'd think about these kind of things but we obviously don't live in an ideal world so we will see when the players arrive and they get checked."
POSSIBLE END-OF-SEASON PARADE
Klopp is likely to have to rely on a number of the younger players who made such an impression at Wembley, with 19-year-olds Bobby Clark and James McConnell likely to start against Saints.
Although the pair have made just one start apiece in cup competitions this season, Klopp has faith in their ability to step up.
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