The Bavarian powerhouses return to continental duty on the back of officially losing their grip on the Bundesliga title, despite a routine 2-0 win over Koln at the weekend.
Bayern's triumph paled into insignificance owing to Bayer Leverkusen's 5-0 crushing of Werder Bremen, which saw Die Werkself crowned top-flight champions for the first time in their history and denied the former holders a 12th successive title.
With only the Champions League left to fight for between now and the end of the season, Bayern seek a repeat of their last two home fixtures with Arsenal in 2015 and 2017, which saw Wednesday's hosts run out 5-1 winners.
Tuchel's men were on course for a 2-1 first-leg success at the Emirates last week as Serge Gnabry and Harry Kane cancelled out Bukayo Saka's strike, but Leandro Trossard was the second-half saviour for Arsenal with a 76th-minute equaliser.
Gnabry, Kingsley Coman ruled out of Arsenal showdownSix minutes before Trossard got Arsenal back on terms, former Gunners academy graduate Gnabry was forced to leave the field with a hamstring strain, which rendered him unavailable for the weekend's clash with Koln.
Instead, Kingsley Coman started on the right flank at the Allianz Arena, but the Frenchman's race was run just five minutes into the second half with an adductor injury, as Jamal Musiala replaced him.
After a statement on Bayern's website revealed that Coman would be out for several weeks, Tuchel confirmed in his pre-game press conference that neither he nor Gnabry would be fit to play any part
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