Spence spent the first half of the season on loan at Leeds United, before the Championship side opted to terminate the loan last month.
The 23-year-old struggled to make a significant impact at Elland Road after spending over two months on the sidelines with a knee injury.
As a result, the 23-year-old was restricted to just seven Championship appearances during his brief stint with Daniel Farke's side.
After returning to Tottenham, Spence was quickly moved on to Genoa, joining the Italian side on loan as part of a deal that saw Radu Dragusin move in the opposite direction.
With a buy option said to be included in the loan deal, the full-back has hinted that he would be open to staying with Genoa beyond the end of the current campaign.
«I knew they had already been looking for me last summer,» Spence told Gazzetta dello Sport. «Now, the right conditions were evidently there to close the operation.
»I'm satisfied. It's an important opportunity. I hope that this can be the beginning of a long journey in a club that is growing.
«I found a nice team and a pleasant city. I settled in quickly. They supported me in everything. Everyone in the locker room has helped.
»There's a nice atmosphere here. Soon I will start studying Italian. For now, I preferred to concentrate on football."
Spence has struggled to establish himself in North London after joining the club from Middlesbrough in a £15m deal in the summer of 2022.
After failing to make an impression under then-manager Antonio Conte, Spence went out on loan to Rennes for the second half of last season.
While Ange Postecoglou is now the man in
Read on sportsmole.co.uk