Joe Gomez makes his Premier League debut as a midfielder as Bobby Clark starts at Nottingham Forest.
Jurgen Klopp makes four changes from Wednesday's win over Southampton in the FA Cup as Luis Diaz, Alexis Mac Allister, Ibrahima Konate and Andy Robertson all return at the City Ground.
Darwin Nunez, Dominik Szoboszlai and Wataru Endo are included as part of the substitutes' bench as Klopp is at least able to add some strength in depth to his match-day squad this afternoon.
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The return of all three will be viewed as a significant boost for Klopp as he juggles his options ahead of a trip to Sparta Prague in the Europa League on Thursday before a huge visit from Manchester City in eight days' time.
Gomez started that victory over the Championship side in the holding midfield position due to the injury crisis engulfing the squad and the in-form and versatile defender reprises the role against Nuno Espirito Santo's side this afternoon, with Mac Allister and Clark slightly further forward.
Up top, Harvey Elliott starts on the right of the front three with Cody Gakpo leading the line and Luis Diaz flanking the left. Young strikers Jayden Danns and Lewis Koumas are on the bench after their goals saw off Southampton in the 3-0 victory.
Liverpool can regain a four-point advantage at the summit of the Premier League this afternoon with victory ahead of Man City's visit from Manchester United on Sunday afternoon.
Liverpool: Kelleher; Bradley, Konate, Van Dijk, Robertson; Gomez, Mac Allister, Clark; Elliott, Gakpo, Diaz.
Subs: Adrian, Endo, Szbosozlai, Nunez, Tsimikas, McConnell, Quansah, Koumas, Danns.
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