Kostas Tsimikas and Darwin Nunez drop to the substitutes bench for Liverpool as they are hosted by Sheffield United.
With this being the second game of a nine-fixture run between December 3 and January 1, Jurgen Klopp makes four changes in total as Ibrahima Konate steps in for the injured Joel Matip.
Matip underwent a scan on Tuesday to discover the severity of what was a suspected knee injury in Sunday's 4-3 win over Fulham with Reds boss Klopp fearful of an extended absence for the centre-back. France international Konate steps in to deputise alongside captain Virgil van Dijk.
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In midfield, it's just a third Premier League start for Wataru Endo with the Japan captain expected to patrol the midfield alongside Alexis Mac Allister and Dominik Szoboszlai, who will occupy the two 'No.8' roles in the engine room.
Up top, Nunez is left on the bench in favour of Gakpo who scored twice against LASK in the Europa League six days ago before an eye-catching cameo in the win over Fulham on Sunday at Anfield. Luis Diaz and Mohamed Salah start on the left and right of the attack respectively to complete the starting XI.
Liverpoolcan close the gap on league leaders Arsenal to two points with a victory over the rock-bottom Blades, who appointed Chris Wilder as their new manager earlier this week after Paul Heckingbottom was relieved of his duties at Bramall Lane.
Liverpool team: Kelleher; Alexander-Arnold, Konate, Van Dijk, Gomez; Endo, Mac Allister, Szoboszlai; Salah, Gakpo, Diaz. Subs: Adrian, Pitaluga, Quansah, Tsimikas, Bradley, Nunez, Elliott, Jones, Gravenberch.
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